He aging is one of the most current concerns. People are more and more aware that the passage of time is inevitable, but taking this path in the healthiest way is possible so as not to have limited aging. Currently there are no miracles or magic elixirsbut nevertheless, A new experiment could have found something revolutionary which once again raises the eternal question: is rejuvenation possible?
So far, stem cell rejuvenation appears to have been the key However, in many anti-aging therapies, the results were doubtful. Even if these stem cells entered the human body, they did not end up integrating into tissues or had a very short lifespan, which did not allow for lasting improvements over time. However, a study published in the scientific journal cell I could have found one possible solution for rejuvenation yes it is possible.
Cells resistant to aging
The IThe researchers started from the basis of these human mesenchymal stem cells which have not finished functioning as expected. In this sense, they decided to risk modify them by improving the function of the FOXO3 genewhich is linked to cellular damage that occurs with age. The most important function of this gene is DNA regeneration, but it also regulates the response to oxidative stress as well as the elimination of damaged cells.
Seeing the “super power” of this FOXO3 gene, The researchers decided to maintain their activity longerwhich made the cells more resistant to the stress and damage of aging. It was then like this They called them cells resistant to aging (senescence-resistant cells).
To continue research, these cells resistant to aging were injected into primates Cynomolguswith a human age between 60 and 70 years for ten months. The researchers injected these cells every two weeks intravenously. surprising result: the rejuvenation of your organs.
Rejuvenated primate organs
Some of the organic improvements that researchers have observed include: increased sensitivity in the brain. After the injections, there were mene cortical atrophy and increased hippocampal connectivityessential for memory and learning. This was also accompanied by an improvement in proteins linked to Alzheimer’s disease. The study therefore reflects that some types of neurons could have declined by up to 6 years in their biological agebased on epigenetic clocks using transcriptomic analysis.
On the other hand, Bone density also improved, chronic inflammation was reduced and tissues such as muscle, intestines and skin were found to have younger molecular patterns.. Likewise, the reproductive systems, which tend to lose activity with age, have also experienced rejuvenation. In the case of females, their oocytes were younger, while in males spermatogenesis improved.
This improvement or rejuvenation occurred, as experts were able to see, thanks to exosomes. The study suggests that these small cellular vesicles loaded with molecular instructions are responsible for being able to reprogram the function of other cells. In fact, by administering only these exosomes, without cells, they were able to observe this rejuvenating power.
Therefore, this undoubtedly opens the door for further research towards safer therapies. Nevertheless, It has only been tested in primates and the significance it may have in humans is not known.the finding of this study should therefore always be considered with caution.
Study reference
Lei, J., . . Liu, G. (2025). Senescence-resistant human mesenchymal progenitor cells fight aging in primates. cell, 188(18), 5039-5061.e35. https://doi.org/10.1016/j.cell.2025.05.021
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