In 2025, the American Society for Reproductive Immunology published its first official guidelines for the immunological management of recurrent miscarriage. The document, based on a systematic review of scientific literature, was mainly written by Brazilian Marcelo Borges Cavalcante, alongside international experts.
The guidelines present patient selection criteria and indicate therapeutic approaches consistent with scientific evidence. Material includes evaluation of intravenous immunoglobulins, lipid infusions, corticosteroids, calcineurin inhibitors, vitamin D, G CSF, cellular therapies, and antithrombotic agents. The document emphasizes that these approaches should only be considered after a detailed study of the immunological profile using specific blood or endometrial analyzes carried out by qualified professionals.
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