Researchers from the University of Brasilia (UnB), with support from the Federal District Research Support Foundation (FAPDF) and the National Council for Scientific and Technological Development (CNPq), are studying wasp venom as a possible way to stop the spread of Alzheimer’s disease.
The substance does not cure the disease, but it can help prevent continued brain damage, especially if used early in treatment.
The discovery came from a simple observation of nature. The hornet’s sting is capable of paralyzing small prey without destroying the nervous system of the attacked animal. This indicates that the substance acts in a specific way, interfering with communication between neurons, without killing the cells.
Based on this perception, Professor Márcia Mortari, from the Institute of Biology at UnB, began to investigate which components of the venom were responsible for this effect. After years of research, scientists succeeded in isolating a molecule with therapeutic potential, which gave birth to Octovespin.
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UnB research studies substance derived from wasp venom that could help slow the progression of Alzheimer’s disease
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Wasp venom is analyzed in the laboratory as a possible ally in the treatment of Alzheimer’s disease
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The study does not speak of a cure, but emphasizes that this compound can protect the brain and preserve memory in the early stages of the disease.
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UnB researchers. Despite the promising results, the study is still in the experimental phase and there is no anticipation of use in humans.
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Despite the promising results, the study is still in the experimental phase and use in humans is not expected.
“It’s a long process. We still need to confirm the safety and effectiveness of the substance before moving on to human testing,” explains Luana Camargo.
According to the researcher, it may take around 10 years for compounds derived from wasp venom to reach more advanced stages of research.
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What happens in the brain in Alzheimer’s disease
In Alzheimer’s disease, a toxic protein builds up in the brain and disrupts communication between neurons. In an attempt to defend itself, the body causes inflammation, which ultimately makes the problem worse.
Over time, connections between brain cells are lost and neurons begin to die, causing memory loss and mental confusion.
According to Luana Camargo, from the Institute of Psychology at UnB, current drugs work mainly by trying to reduce this protein, but they are unable to prevent the brain from further deterioration.
“What we observed is that Octovespin acts to protect neurons and reduce inflammation in the brain. It does not cure Alzheimer’s disease, but it helps slow the progression of the disease,” explains the researcher.
In tests on mice, animals treated with the substance showed less forgetfulness. “This indicates that the compound helps maintain brain functions for longer, especially when used in the early stages of the disease,” explains Luana Camargo.
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